Health Tips From The Professor Does Vitamin D Reduce Cholesterol In Children?

 

Posted August 7, 2018 by Dr. Steve Chaney

Is Vitamin D Associated With Heart Disease Risk?

Author: Dr. Stephen Chaney

vitamin-d-reduce-cholesterol-childrenNot too many years ago, we thought of vitamin D as affecting bone density and little else. Then we discovered that almost every cell in our body has vitamin D receptors. This has lead to research suggesting that vitamin D affects our health in many ways that were unimaginable only a couple of decades ago.

For example, low vitamin D levels are associated with increased risk of heart disease. The linkage between vitamin D and heart disease has not been proven. Nor do we know the mechanism. However, this has lead to ongoing research asking if there is any relationship between vitamin D and cholesterol metabolism.

The answer appears to be yes. Several studies have suggested a correlation between low vitamin D levels and elevated total cholesterol, LDL cholesterol, and triglycerides – all risk factors for heart disease.

The next question is how early in life is this correlation found. Again, some studies have suggested that the same correlation between low vitamin D and high levels of unhealthy lipids are found in teens. But, what about pre-teens, children who haven’t gone through puberty yet? That’s what this study was designed to determine.

How Was The Study Done?

vitamin-d-reduce-cholesterol-children studyThe current study  was based on data collected from 419 children, ages 6-8, in the Physical Activity and Nutrition in Children (PANIC) Study in Eastern Finland. This was a lifestyle study that collected information on body weight, diet, and activity levels.

Fasting blood samples were also collected and analyzed for blood lipid levels (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) and for 25-hydroxyvitamin D (25(OH)D), which is considered the most accurate measure of vitamin D status. The National Institutes of Health considers:

  • <30 nmol/L of 25(OH)D an indicator of vitamin D deficiency.
  • 30 to <50 nmol/L 25(OH)D an indicator of vitamin D insufficiency.
  • ≥50 nmol/L 25(OH)D an indicator of adequate vitamin D status.

To put this study in perspective, vitamin D status is a major concern in Finland because of its proximity to the Arctic Circle. There is little sunlight in the winter, and, although the days are long in the summer, the sun is weak. The major sources of vitamin D in the Finnish diet are fish, vitamin D-fortified fluid milk products, vitamin D-fortified fat spreads, and vitamin D supplementation. Vitamin D fortification was introduced in Finland in 2003. Vitamin D supplementation has also become increasing popular. The number of people using vitamin D supplements has increased from 11% in 2000 to 41% in 2011.

A recent study  looking a vitamin D status between 2000 and 2011 found that the combination of food fortification and vitamin D supplementation has been successful at improving vitamin D status in the Finnish population, increasing average 25(OH)D levels from 48 nmol/L to 65 nmol/L.

 

Does Vitamin D Reduce Cholesterol In Children?

vitamin dIn this study the mean serum 25(OH)D in the children was 68.1 nmol/L. 20% of the children had serum 25(OH)D below 50 nmol/L, and only 4 children (1%) had serum 25(OH)D below 30 nmol/L. When 25(OH)D levels were compared with blood lipid levels:

  • Higher serum 25(OH)D levels Forskolin Keto Complete were associated with lower plasma levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides.
  • The association between higher 25(OH)D levels and lower blood levels of total cholesterol, LDL cholesterol, and HDL cholesterol remained after correcting for weight, physical activity, sedentary behavior, diet, daylight time, parental education, and genetic mutations known to affect vitamin D metabolism.

What Does This Mean For You?

I don’t want to overinterpret the study. Not all studies show an inverse association between 25(OH)D and cholesterol levels. Most of the previous studies have also indicated that higher 25(OH)D levels were associated increased HDL levels, while this study found higher 25(OH)D levels associated with decreased HDL levels. Much more research needs to be done.

However, this study is yet another indication that optimal vitamin D status may be important for heart health, even in young children. While the correlation between vitamin D status and heart health is not definitive at present, virtually everyone agrees that adequate vitamin D status is a good thing.

My recommendations are to:

  • Get as much vitamin D as possible from vitamin D-fortified foods, oily fish, and sensible sun exposure.
  • Get your serum 25(OH)D level determined and take vitamin D supplements if it is low.

The Bottom Line

A recent study of vitamin D status in Finnish children ages 6-8 found:

  • Higher vitamin D status was associated with lower plasma levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides.
  • The association between better vitamin D status and lower blood levels of total cholesterol, LDL cholesterol, and HDL cholesterol remained after correcting for weight, physical activity, sedentary behavior, diet, daylight time, parental education, and genetic mutations known to affect vitamin D metabolism.

This study is another indication that optimal vitamin D status may be important for heart health, even in young children. While the correlation between vitamin D status and heart health is not definitive at present, virtually everyone agrees that adequate vitamin D status is a good thing.

My recommendations are to:

  • Get as much vitamin D as possible from vitamin D-fortified foods, oily fish, and sensible sun exposure.
  • Get your serum 25-hydroxyvitamin D level determined and take vitamin D supplements if it is low.
  • Make sure your children are getting enough vitamin D in their diet and have optimal serum 25-hydroxyvitamin D.

For more details, read the article above.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.

Health Tips From The Professor Iron Deficiency In Children May Negatively Affect Their Brains

Posted July 3, 2018 by Dr. Steve Chaney

Is Your Teen Getting Enough Iron?

Author: Dr. Stephen Chaney

 

iron deficiency in childrenFor those of you with teenagers – or who have had teenagers in the past – you may suspect that there’s nothing between their ears. But actually, there is a lot going on between their ears, and some of the neural contacts laid down in the brain during the teen years influence the health of their brain during their adult life.

And – no surprise here – what they eat can affect the health of their brain as well.  Iron deficiency in children may negatively affect their brains later in life.

Which brings me to a study (N. Jahanshad et al, PNAS 109 E851-E859, 2012 ) that looks at the adequacy of dietary iron intake during the teenage years and their brain health as adults.

 

Basics of Iron Metabolism

 

iron deficiency in children metabolismBefore I describe the study perhaps a little bit of what I call Biochemistry 101 is in order.

Free iron is toxic to living cells. For that reason, our body produces multiple proteins to bind and transport the iron. The protein that binds and transports iron through the bloodstream is called transferrin. Under normal conditions 2/3 of the transferrin in our bloodstream has iron bound to it and 1/3 does not. And that is the ideal ratio of bound and unbound transferrin for delivery of iron to brain cells and other cells in our body.

When our diet is iron deficient (or we have excessive blood loss) the percent iron saturation of transferrin decreases. The body tries to compensate by producing more transferrin, but this doesn’t really help since the problem was inadequate iron supply, not inadequate transferrin supply. Consequently, elevated transferrin levels are generally indicative of an iron-deficient diet.

 

Iron Deficiency In Children

 

The study was led by Dr. Paul Thompson of the UCLA Department of Neurology. He and his team performed brain scans on 631 healthy young adults with an average age of 23. The brain scans were of a type that measured strength and integrity of the connections between the nerves in the brain – in other words, the brain’s wiring. They then went back and looked at the amount of iron available to each subject’s brain during adolescence by looking at their blood transferrin levels from routine physical exams performed at ages 12, 14 and 16 (blood transferrin levels are often measured as part of routine physical exams).

The results were clear cut. Elevated transferrin levels during the teenage years were associated with reduced brain-fiber integrity in regions of the brain that are known to be vulnerable to neurodegeneration. These individuals did not show any cognitive impairments as young adults, but the concern is that they might be more likely to develop cognitive impairments as they age.  From this, we can determine iron deficiency in children may make them susceptible to mental disease as they age.

Dr. Thompson summarized his team’s findings by saying that “Poor iron levels in childhood erode your brain reserves which you need later in life to protect against aging and Alzheimer’s. This is remarkable, as we were not studying iron deficient people, just around 600 normal healthy people. It underscores the need for a balanced diet in the teenage years, when your brain command center is still actively maturing.”

 

Questions Every Parent Should Ask

If you have teenagers, you might want to ask yourself questions like:

  • What is your teenager’s diet like?
  • Is it balanced?
  • Are you sure that it meets their nutritional needs?
  • Should you consider supplementation to make sure that they are getting all the nutrients that they need?

 

The Bottom Line

 

  • A recent study suggested that inadequate iron intake in the teenage years may affect how our brains are wired in our adult years. The authors of the study interpreted the study as suggesting that an inadequate diet during the teen years could predispose us to cognitive decline and Alzheimer’s as adults.
  • This study only looked at structural differences in the brain circuitry. We can’t conclude from this study alone that inadequate iron intake as a teenager will doom somebody to cognitive impairment and increased Alzheimer’s risk as they age. But we can conclude that adequate iron intake during adolescence is required for normal brain development.
  • And it’s probably not just iron. This study focused on iron status because transferrin levels are routinely measured during physical exams, so it was easy to go back and determine what each subject’s iron status was during their teenage years. Many other important nutrients are required for normal brain development, but we don’t have an easy way of going back and determining what someone’s nutritional status was for those nutrients in their teen years. What was shown to be true for iron in this study is likely to be true for other nutrients as well.
  • These were normal teens eating a normal American diet. They weren’t from a third world country and there was nothing weird about what they were eating. But, clearly some of the subjects in the study weren’t getting the iron that they needed from diet alone.
  • The teen years are a time of rapid growth and maturation. It’s not just the brain that needs the proper balance of nutrients during the teen years. All their tissues require proper nutrition.

 

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure or prevent any disease.